Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function (Open Access Article)

This month's open access article features several University of Missouri School of Medicine Faculty:

  1. Dr. Javad Habibi, PhD., Dr. Annayya Aroor, MD., Dr. Guanghong Jia, PhD., and Dr. Vincent DeMarco, PhD. are all Assistant Research Professors in the department of Endocrinology, Diabetes, and Metabolism. 
  2. Dr. Jim Sowers, MD., is a Professor of Medicine, Physiology/Pharmacology, Vice Chair for Research in the Department of Internal Medicine, and Director of the Endocrinology, Diabetes & Metabolism Division. In 2017, Dr. Sowers was awarded the Samual Eichold II Memorial Award for Contributions in Diabetes from the American College of Physicians. The award recognizes those who have made important health care delivery innovations for diabetic patients or research that significantly improves quality of care or clinical management of diabetes. 
  3. Dr. R. Scott Rector, PhD., is an Associate Professor in Internal Medicine-Division of Gastroenterology and Hepatology. Dr. Rector's primary research interests include the role of exercise training, lifestyle modifications, and pharmacological interventions upon oxidative stress and liver metabolism. 
  4. Dr. Adam Whaley-Connell, DO., is an Associate Professor of Medicine and Associate Chief of Staff for Research and Development. His research interests include hypertension, and kidney disease. 

The research team's article, Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodent model of diabetes was published in Cardiovascular Diabetology in January 2017. Cardiovascular Diabetology is an open access journal that publishes research on all "aspects of the diabetes/cardiovascular interrelationship and the metabolic syndrome; this includes clinical, genetic, experimental, pharmacological, epidemiological and molecular biology research." With a high impact factor and maxiumum visibilty of articles due to their open access policy, this journal has a wide and global audience. 

Here is an excerpt from the abstract:

Obese and diabetic individuals are at increased risk for impairments in diastolic relaxation and heart failure with preserved ejection fraction. The impairments in diastolic relaxation are especially pronounced in obese and diabetic women and predict future cardiovascular disease (CVD) events in this population. Recent clinical data suggest sodium glucose transporter-2 (SGLT2) inhibition reduces CVD events in diabetic individuals, but the mechanisms of this CVD protection are unknown. To determine whether targeting SGLT2 improves diastolic relaxation, we utilized empagliflozin (EMPA) in female db/db mice.

In summary, EMPA improved glycemic indices along with diastolic relaxation, as well as SGK1/ENaC profibrosis signaling and associated interstitial fibrosis, all of which occurred in the absence of any changes in BP.

 

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Taira Meadowcroft

Taira Meadowcroft is a Health Sciences Librarian at the University of Missouri. She focuses on quality improvement, emergency medicine, and social media for the health sciences library.

Dr. Loboa: Enhanced cellular infiltration of human adipose-derived stem cells in allograft menisci using a needle-punch method (Open Access Article)

This week's open access article features Dr. Elizabeth Loboa, Dean of the College of Engineering, and professor of bioengineering. Her research and techincal focuses are tissue engineering & biomaterials, regenerative medicine and wound healing, and stem cells. Take a look at Dr. Loboa's faculty profile to learn more about her role as the dean, as well as her research. 

Dr. Loboa, with her research team, published in the Journal of Orthopedic Surgery and Research (JOSR) back in October. Journal of Orthopaedic Surgery and Research is an open access, peer-reviewed online journal that encompasses all aspects of clinical and basic research studies related to musculoskeletal issues. JOSR encourages the publication of multidisciplinary research with collaboration amongst clinicians and scientists from different disciplines, which will be the trend in the coming decades. This is why her article is also featured. Dr. Loboa's article is an interdiscplinary collaboration with medicine and engineering. 

Her research in Enhanced cellular infiltration of human adipose-derived stem cells in allograft menisci using a needle-punch method, looked to provide a new method for enhanced cellular infiltration in meniscal allografts. The memiscus is crucial in knee joint function in terms of join stability, and allowing shock absorption, and stress distribution. Their new approach was found to better help better remodel post-surgery, and improve long-term efficacy of meniscal transplantation. 

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Taira Meadowcroft

Taira Meadowcroft is a Health Sciences Librarian at the University of Missouri. She focuses on quality improvement, emergency medicine, and social media for the health sciences library.

Downs and Dalabih: The risk of shorter fasting time for pediatric deep sedation (Open Access Article)

This week's Open Access article features two University of Missouri Faculty. 

  • Dr. Craig Downs, DO., is an Assistant Professor of Clinical Child Health. Dr. Downs primary interest is pediatric critical care.  If you would like to learn more about Dr. Downs click here
  • Dr. Abdallah Dalabih, MD., MBA, is an Assistant Professor of Clinical Child Health. He is involved in clinical research in pediatric critical care and sedatio, with one other study accepted for publication and four others that are in the process of submission. Those four projects will be published by two medical students and two pediatric residents all as first authors. Click here for Dr. Dalabih's faculty profile. 

Dr. Downs, Dr. Dalabih, and their research team published in Anesthesia: Essays and Researches, an open access peer-reviewed international journal by the Pan Arab Federation of Societies of Anesthesiologists. The journal covers technical and clinical studies related to Anesthesia, pain management, intensive care and related topics including ethical and social issues.

Their research in The risk of shorter fasting time for pediatric deep sedation, investigates that safety of a shorter fasting time compared to a longer fasting time before pediatric procedural sedation and analgesia. The current guideline, adopted by the American Academy of Pediatrics, calls for prolonged fasting times. This prospective observational study tries to identify the association between fasting times and complications related to sedation. 

 

Dr. Dalabih took the time to answer some questions we had about open access:

Why did you choose to publish in an Open Access journal?

We selected a journal that is indexed at PubMed so it would be easy to find and that can be accessed all over the world. The journal of Anesthesia: Essays and Researches is an open access journal and is indexed at PubMed with no publication fees, so we elected that journal to showcase our research project.

Would you publish in an Open Access journal again?  If so, why?

Yes, with the increased prices of subscriptions, libraries and physicians are having some difficulty accessing articles they need. This is especially true at countries with poor economies. Open access journals allows those physicians to benefit from the study and will increase the distribution. 

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Taira Meadowcroft

Taira Meadowcroft is a Health Sciences Librarian at the University of Missouri. She focuses on quality improvement, emergency medicine, and social media for the health sciences library.

Promoting Open Access Research @ MU

Open Access week is an important week. A week dedicated to highlighting the importance of Open Access and advocating for free, and immediate online access to scholarly research. This year’s theme, “Open in Action,” is all about taking concrete steps to open up research and scholarship and encouraging others to do the same. This was the purpose in creating an open access blog; a way to share research MU faculty choose to publish open access.

Every few weeks, I post about an open access article, right here on our library news page. When typing up the post, I focus on the research itself, the academic accomplishments of the faculty, and the most important, the reasons why they chose to publish in open access. I've received several insightul thoughts on why they think open access is important, and to my great delight, all look fantastic as graphics. 😉 Marketing material aside, they are profound thoughts that I hope will strike a chord with other MU faculty, and scholars outside the university, further engaging others and promoting the open access initiative. 

 

copy-of-would-you-publish-open-access-again-1why-open-access-social-media-3

 

October 22nd-October 24th, I presented a poster at Merge&Converge'16, the 2016 Mid-Continent Medical Library Association conference. I wanted to show others that promoting open access, and engaging faculty is easier than we think. Faculty can be open access champions.

 

tairamcmlaposter2016

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Taira Meadowcroft

Taira Meadowcroft is a Health Sciences Librarian at the University of Missouri. She focuses on quality improvement, emergency medicine, and social media for the health sciences library.

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers (Open Access)

This week's Open Access article features two University of Missouri Faculty. 

  • Dr. Deborah Chance PhD., is an Assistant Research Professor in the Molecular Microbiology and Immunology Department at the School of Medicine. Dr. Chance's primary research interest is mucins and pathogens in Cystic Fibrosis. If you would like to learn more about Dr. Chance, click here
  • Dr. Thomas Mawhinney, PhD., is a Professor in the Department of Biochemistry at the University of Missouri. He is also the State Chemist of Missouri, and the Director of the Agricultural Experiment Station Chemical Laboratories. Click here to learn more about Dr. Mawhinney

Dr. Chance, Dr. Mawhinney, and their research team pubished in JoVE, the Journal of Visualized Experiments. JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research.

This research team chose to pay an additional fee to make Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization open access. Their article/video features "an efficient, three-step synthesis of RAFT-based fluorescent glycopolymers, consisting of glycomonomer preparation, copolymerization, and post-modification, is demonstrated. This protocol can be used to prepare RAFT-based statistical glycopolymers with desired structures." Synthetic glycopolymers are instrumental in various biochemical and biomedical research fields. 

Drs. Lin, McElroy, and Nagel: Endocrine-Disrupting Chemicals and Oil and Natural Gas Operations (Open Access)

This week's Open Access blog post features, not one, not two, but three University of Missouri Faculty:

  • Dr. Chung-Ho Lin, PhD., is an Assistant Research Professor in the School of Natural Resources. Dr. Lin's primary research involves the use of plants and genetics modified microbes for applications in the area of phytoremediation and bioremediation in agroforestry. Click here to learn more. 
  • Dr. Jane McElroy, PhD., in an Associate Professor of Family and Community Medicine in the School of Medicine. Dr. McElroy's research interests include cancer and chronic disease, environmental exposures with metals, and geographical information systems. Click here to learn more about Dr. McElroy.
  • Dr. Suan Nagel, PhD., is an Associate Professor of Obstetrics, Gynecology, and Women's Health in the School of Medicine. Dr. Nagel's clincal and research interests include endocrine disruption, fetal origins of adult disease, and epigenetics, to name a few. To learn more about Dr. Nagel, click here

This research team published in the open access journal Environmental Health Perspectives back in March. Environmental Health Perspectives is "a monthly peer-reviewed journal of research and news published with support from the National Insititure of Environmental Health, National Institutes of Health, and the U.S. Department of Health and Human Services."

Their article, Endocrine-Disrupting Chemicals and Oil and Natural Gas Operations: Potential Environmental Contamination and Recommendations to Assess Complex Environmental Mixtures, is a commentary on hydraulic fracking technologies and the potiential for environmental release of oil and gas chemicals and potential endocine-related health effects from exposure to the hazardous chemcials. They describe a need for an endocrine componement to health asssessments conducted in regards to hydraulic fracking. 

Dr. Franz: Infection pattern and transmission potential of chikungunya virus (Open Access)

Dr. Alexander Franz, Ph.D. is an assistant professor in the department of Veterinary Pathology at the College of Veterinary Medicine. His research focuses on mosquito-borne arboviruses and their interaction with the mosquito. Recently, his team became involved in studying Zika virus, i.e. developing an animal model, in collaboration with Dr. Jeff Adamovicz (Dept. of Veterinary Pathobiology, MU), and Dr. Carl Gelhaus, (MRI-Global, Kansas City); in collaboration with Dr. R. Michael Roberts (Life Sciences Center, MU), [they] are taking part in the investigation of the mechanism allowing Zika virus to infect human placenta-derived cells. If you would like to learn more about Dr. Franz, click here,

Dr. Franz, along with Dr. Shengzhand Dong and their research team, published in Scientific Reports, an online open access scientific mega journal published by the Nature Publishing Group.. In August, a blog post on the Scholarly Kitchen, mentioned that the journal is likely to become the biggest one in the world, overtaking the open access journal, PLOS ONE. Their article, Infection pattern and transmission potential of chikungunya virus in two New World laboratory-adapted Aedes aegyptistrains, discusses the mosquite-borne Chikungunya virus and its infection pattern.  

 

Why did you choose to publish in an Open Access journal?

"We were interested in reaching a broad audience also in countries/institutions that may not be able to afford high-price journal subscriptions and therefore rely on open access articles to get informed about scientific developments/discoveries. This is especially useful when working on things like tropical disease agents, which often are a problem in countries that do not have a rich science infrastructure."

Would you publish in an Open Access journal again?  If so, why?

"Yes, I would. I like the concept of open access even though it means that we (as authors) have to pay for the publication. But ususally, it also means that we (as authors) retain the copy rights of our work."

Dr. Beucke: Out of the classroom and into the community (Open Access)

Dr. Nathan Beucke, MD., is an Assistant Professore of Clinical Child Health at the University of Missouri School of Medicine. His research interests include General Pediatrics, Newborn Care, and Pediatric/Childhood Obesity. If you would like to learn more about Dr. Beucke, click here

Dr. Beucke, along with several MU medical and graduate students, recently published in BMC Medical Education, an "open access journal publishing original peer-reviewed research articles in relation to the training of healthcare professionals, including undergraduate, postgraduate, and continuing education. The journal has a special focus on curriculum development, evaluations of performance, assessment of training needs and evidence-based medicine." Dr. Beucke's article, Out of the classroom and into the community: medical students consolidate learning about health literacy through collaboration with Head Start, discusses the Eat Healthy, Stay Active! program, a pediatric obesity prevention program implemented at Head Start, over an academic year. 

Dr. Mehr: Impact of a decision-making aid for suspected urinary tract infections on antibiotic overuse in nursing homes (Open Access)

Dr. David Mehr, M.D., is a William C. Allen Professor in Family Community Medicine and Director of Research at the University of Missouri School of Medicine. Dr. Mehr was awarded a $4.5 million federal grant to support a new Center for Patient-Centered Research Outcomes at MU. This interdisciplinary study is bringing together experts from across campus to investigate how to help patients and physicians understand which prevention and treatment options are best for each individual, especially patient who are older and/or dealing with complex chronic diseases.Construction is currenlty underway for the Patient-Centered Care Learning Center.

If you would like to read more about Dr. Mehr, click here for his profile. 

Dr. Mehr recently published in BMC Geriatrics, an open access journal that publishes original peer-reviewed research articles in all aspects of the health and healthcare of older people, including the effects of healthcare systems and policies. The journal also welcomes research focused on the aging process, including cellular, genetic, and physiological processes and cognitive modifications.

McMaughan, D. K., Mehr, D. et al. (2016). "Impact of a decision-making aid for suspected urinary tract infections on antibiotic overuse in nursing homes." BMC Geriatrics 16(1): 1-9.

Dr. Brogan: A critical analysis of the review on antimicrobial resistance report and the infectious disease financing facility (Open Access)

Dr. David Brogan MD, MSc is an Assistant Clinical Professor of Orthopedic Surgery at the School of Medicine. He won the Brian Abel Smith Prize for Health Policy Dissertation at the London School of Economics, a resident research grant from the American Society for Surgery of the Hand, as well as a recent KL2 Mentored Career Development Award.  He has also co-authored multiple publications with the London School of Economics on a range of health policy topics, particularly focusing on the utilization of financial call options to stimulate neglected research. This is an ongoing collaboration with the London School of Economics and the Missouri Orthopedic Institute.

For more information on Dr. Brogan's research interests and publications, click here

Dr. Brogan recently published in Globalization and Health, transdisciplinary journal that situates public health and wellbeing within the dynamic forces of global development.

Brogan, D. M., & Mossialos, E. (2016). A critical analysis of the review on antimicrobial resistance report and the infectious disease financing facility. Global Health, 12, 8. doi:10.1186/s12992-016-0147-y

Here are some of Dr. Brogan's thoughts on Open Access:

Why did you choose to publish in an Open Access journal?

  • I’m quite pleased with the idea that open access journals enhance the abilities of all interested parties to learn more about a topic and greatly enhance the exchange of ideas across may disciplines.

Would you publish in an Open Access journal again?  If so, why? 

  • Yes, absolutely, it was a great experience and I would welcome the opportunity to do so again.